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Carvedilol treatment mitigated hepatic enzyme damage, restored oxidative balance, modulated inflammatory state, and regulated endothelial (eNOS) and inducible (iNOS) nitric oxide synthase expression ( 7 Conclusion and future perspectives Based on the review of the impact of -blockers on glucose metabolism, insulin sensitivity, oxidative stress and inflammation, several conclusions and future perspectives can be drawn

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Fluorescent signals were normalized using F / F baseline where F is fluorescence at a given time-point and F baseline is average fluorescence between 2 and 4 min

Marcondes FK, Bianchi FJ, Tanno AP (2002) Determination of the estrous cycle phases of rats: some helpful considerations