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Chronic or repeated HPA axis stimulation raises legitimate concerns, as sustained cortisol elevation is associated with insulin resistance, altered body composition, bone loss, immune modulation, and cardiovascular effects

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Likewise, BPC 157 may interfere with prostaglandin system activities, that is, it strongly counteracts NSAIDs toxicity (Sikiric et al., 2013), much like it counteracts developing and already formed adjuvant arthritis in rats (Sikiric et al., 1997c)