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The Duration: This is the most critical difference
These authors concluded that the proportion of LBM relative to total body mass increased with semaglutide. Similarly, in the SURMOUNT-1 trial which studied tirzepatide, researchers found that participants treated with tirzepatide had a percent reduction in fat mass approximately 3 times greater than the reduction in lean mass, resulting in an overall improvement in body composition. More recently, a viewpoint in JAMA re-grounded the conversation: weight loss in persons with obesity primarily reduces body fat, but also decreases fat free mass (FFM)
Blood Cells, Molecules, and Diseases, 40(2), 174-179
Other developments include the ending of patents for DPP-4 inhibitors, which began in 2022 for sitagliptin and which will follow for other DPP-4 inhibitors in the coming years
We are currently in an internal evaluation phase, reviewing the published research and running a structured internal protocol with our clinical team
