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This is also in agreement with other studies reporting amplified sartan-induced thermal fluctuations that uncouple the bilayer stacks [304, 305], most likely due to a softening of the membrane as expected from the reduction in the area per lipid

The scientific studies of these experimental drugs were never large enough or long enough to establish a clear safety profile, so all we are left with are vague reassurances from tiny studies and testimonials from YouTubers and TikTokers

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