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Experimental systems consistently observe measurable reductions in feeding behavior within defined observation periods

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Beyond the pancreas, GLP-1R is expressed in the brain (particularly the hypothalamus, brainstem NTS, and reward circuitry), heart, kidney, lung, gastrointestinal tract, bone, and immune cells

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When the receptor is engaged, it kicks off intracellular signaling cascades that drive both protein-building activity and cell proliferation

FMT, fecal microbiota transplantation