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These cells also had higher expression of the pericyte marker platelet-derived growth factor receptor ( Pdgfrb ) and the EC marker platelet EC adhesion molecule ( Pecam1 ), and they were relatively depleted for Protein tyrosine phosphatase receptor type C ( Ptprc ), which encodes for CD45 (Figure 7H)

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Additionally, the creation of new GLP-1 therapies remains highly sensitive to safety signals like Pfizers decision to discontinue an oral GLP1 candidate after a single potential liver-related event during development

Markers to watch include: Vitamin B12 levels may decrease over time, especially in people with reduced dietary intake or those combining semaglutide with metformin (which independently reduces B12 absorption)