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During viral infections, however, the rate of intracellular ROS production exceeds the antioxidant capacity in cells, causing oxidative stress, which consequently leads to the depletion and deficiency of antioxidant enzymes, such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), and the depletion of non-enzymatic free radical scavengers such as vitamin E (-tocopherol), vitamin C (ascorbate), glutathione (GSH), -carotene, and melatonin [296, 297, 299,300,301]

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Limited data mostly from case-control studies are available to assess whether citicoline (CDP-choline) might improve cognitive performance in subjects with AD or PD, and studies to date have generally been labeled as poor in quality (84)

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J.VuppalanchiR.BoursierJ.BugianesiE.et al (2024)

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