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It shares 94% sequence homology with human GLP-1 but has been structurally modified to resist rapid enzymatic breakdown, giving it a significantly extended half-life compared to native GLP-1

That includes anyone with a hypersensitivity to the GLP-1 agonist, anyone with a family history or personal history of medullary thyroid cancer, or those with a history of pancreatitis

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Short-acting preparations include beinaglutide (BN) and exenatide (EX), which generally need to be injected 2-3 times a day

Vomiting affected 31% of high-dose participants, while diarrhea occurred in 23% of patients

Federal health authorities continue to flag significant clinical concerns, including immunogenicity risks and the theoretical potential to stimulate oncogenic (cancer) pathways