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Nuclear receptors constitute a superfamily of ligand-activated transcription factors, which regulate critical physiological processes including growth, development, hormonal signals, reproduction, and energy metabolism (Sonoda et al., 2008)

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This is called atrophic glossitis

395 Intriguingly, even in instances where allopurinol is not adjusted according to the estimated glomerular filtration rate (eGFR), approximately one-third of patients fail to attain SU levels below the designated threshold of 6.0 mg/dL