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In one study, participants who consumed a spermidine-rich diet for 3 months exhibited improved insulin sensitivity and lower fasting glucose levels, suggesting spermidines potential as a therapeutic agent for managing metabolic disorders (Reference Wirth, Benson and Schwarz99)
More recently, a combination of atomoxetine and pimavanserin, a serotonin 5HT2 A receptor antagonist, was investigated in a small cohort of patients with moderate-to-severe OSA in an attempt to counteract atomoxetines noradrenergic effects and wakefulness-promoting properties
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