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Metformin HCl Metformin is substantially excreted by the kidney, and the risk of metformin accumulation and lactic acidosis increases with the degree of renal impairment [see Warnings and Precautions (5.1)]
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Importantly the patient should not increase the dose of their medication as scheduled if there is any significant nausea, diarrhoea or constipation
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Safety and efficacy of Efruxifermin in combination with a GLP-1 receptor agonist in patients with NASH/MASH and type 2 diabetes in a randomized phase 2 study