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They are included to explain what researchers may see online and how the timelines differ

Decrease dose if: Experiencing consistent side effects (headaches, fatigue, GI disturbance), achieving satisfactory results at current dose with no need for escalation, or cost considerations favor using minimum effective dose

Heavy metals accumulate in biological tissue and produce confounding effects in long-term studies

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The dosage protocol matters because TB-500s mechanism relies on sustained tissue signaling rather than a single acute dose