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TsengPTZengBYChenJJKuoCHZengBSKuoJSet al
doi: 10.1155/2018/7402947 8
The cumulative load is called oxidative stress
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MOTS-c modulates the FOXO transcription factors and regulates cellular senescence, the state in which aged or damaged cells stop dividing but refuse to die, instead secreting a cocktail of inflammatory signals known as the senescence-associated secretory phenotype (SASP)
This determines whether PT-141 is the appropriate primary intervention, whether hormonal or vascular components also need to be addressed, and whether combination therapy would produce better outcomes
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