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Sohal RS, Forster MJ

This Journal Club focuses on the SELECT Trial Table of contents for the The SELECT Trial summary: Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes A

Activation of the GLP-1Rs leads to a small increase in intracellular cAMP, sufficient to activate PKA with resultant inhibition of glucagon secretion

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These symptoms typically diminish over several weeks as tolerance develops