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SELECT (NEJM 2023) established the CV benefit: 17,604 adults with established CVD and overweight or obesity, 20% reduction in major cardiovascular events over a mean 40 months

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The androgen-positive effects on muscle growth might be also elicited through the Notch signaling

In patients with pregestational diabetes, there were no significant differences between those with and without preconception GLP-1 exposure in terms of how many gained more or less weight than recommended

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