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On a biological level, the molecule restored the balance of antioxidant defenses (GST, GSH, and catalase) while reducing lipid peroxidation (LPO)
Figure 6 Protein Expressions of Apoptotic and Inflammatory Markers Western blotting revealed that the protein expressions of the cleaved forms of PARP and caspase 3 were significantly upregulated in the HFC group, and these changes were not eliminated in the KD group
The peptide has also been investigated as a regulator of the sleep cycle, as it increases levels of melatonin and endogenous gonadotropic hormones (FSG, LG, prolactin), which play a role in reproductive function but naturally decline with age [8]
The interplay between NF-B and Nrf2 pathways is crucial in managing OS and inflammation, as seen in the effects of dietary phytochemicals that can activate these defense systems (Wu et al., 2022)
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