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Conclusion Obesity pharmacotherapy in older adults should be encouraged as an adjunct to energy-restriction and physical activity, with an emphasis on resistance training

By tracking specific health metrics beyond total weight, we focus on preserving muscle mass while targeting fat loss

GLP-1 receptor agonists are currently among the most widely discussed classes of drugs worldwide

The FDA and Novo Nordisk did not immediately respond to requests for comment

For this reason, when weight management is the primary objective, clinicians often select the brand that allows escalation to the evidence-based target dose

In a particularly relevant example, SERCA2a gene transfer was used in the late stages of pressure-over-load-induced hypertrophy, preceding the transition to failure 31