The absolute risk is low, but its higher than in the general population
The analysis included data from 18,742 patients with type 2 diabetes mellitus (T2DM) receiving 5.0mg, 10.0mg, or 15.0mg once-weekly subcutaneous tirzepatide or 0.5mg, 1.0mg, or 2.0mg once-weekly subcutaneous semaglutide for at least 12 weeks
The same outlet also reports that researchers suspect GLP-1 drugs act on reward signalling in the brain
Clinical trials indicate a reduction in major adverse cardiovascular events, offering an added layer of protection for individuals with diabetes who are at an increased risk of cardiovascular complications
While NSAIDs impair recovery through gut injury, nutrient depletion, cardiovascular strain, and delayed tissue repair, opioids alter pain through a fundamentally different mechanismsuppressing central pain perception without addressing inflammatory or structural drivers
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