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In addition to its effects on metabolic regulation, GLP-1, when synthesized within the brain, exhibits neuroprotective properties.397,427,431 A clinical trial titled Liraglutide in Early Parkinsons Disease was published in the New England Journal of Medicine, exploring the effects of liraglutide on patients with early-stage PD diagnosed within the last three years.432 The research was a 14-month Phase II double-blind randomized controlled trial
Epigallocatechin-3-gallate enhances clearance of phosphorylated tau in primary neurons
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Mateescu DM, Gavrilescu DM, Constantinescu FE, et al
By harnessing the complementary biology of two endogenous hormones, these agents achieve metabolic effects on glycemia, body weight, lipid handling, and cardiovascular risk that neither hormone can fully replicate alone