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A key study published in the Journal of Clinical Endocrinology and Metabolism enrolled 118 GH-deficient adults and demonstrated a 30-40% increase in serum IGF-1 over 6 months of nightly subcutaneous dosing

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In the REDEFINE-1 Phase 3 trial, people on CagriSema lost an average of 22.7% of their body weight over 68 weeks when accounting only for those who stayed on treatment

Bile acids serve as signaling molecules that activate nuclear receptors like the farnesoid X receptor (FXR) and Takeda G protein-coupled receptor 5 (TGR5) in the liver and intestine (139, 140)