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Battiste, J
Studies have shown that JNK, when combined with Sab, which is a scaffold protein located in the outer membrane of mitochondria, triggers the destruction of mitochondrial electron transport chain and promotes the release of reactive oxygen species (ROS), ultimately resulting in cell death (71, 72)
In this study, we identify key enzymes in the serine synthesis pathway (SSP), namely PHGDH, PSAT1 and PSPH, as well as the serine transporter SLC1A4, which are significantly overexpressed in lung cancer and correlate with poor patient prognosis
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