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PMID 17049946

If neurological symptoms worsen or fail to improve after four to six weeks of appropriate treatment , further investigation is necessary to exclude alternative diagnoses or complications

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Despite elevated intracellular GSH levels and increased redox cycling activity, the transcriptomic data indicated downregulation of Gss (glutathione synthetase), Gclc (glutamate cysteine ligase catalytic), and Chac1 (a canonical GSH-degrading enzyme), alongside significant upregulation of Chac2, a less characterized homolog involved in glutathione regulation (Fig

This can cause side effects like joint pain, water retention, and possibly increased blood pressure