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Avoid administration immediately after meals, particularly high-carbohydrate meals

All patients will be adequately informed, both verbally and in writing, of the nature of the trial, its aim, and its risks and possible benefits

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[1] [2] However, longstanding neurological complications, such as peripheral neuropathy or cognitive changes, may require three to six months of consistent treatment before significant improvement occurs, and some damage may be irreversible if treatment is delayed