glp-1 euglycemic dka diabetic ketoacidosis in the era of SGLT-2 inhibitors Balancing the benefits and risks

The dosing regimen varies depending on whether neurological symptoms are present: With neurological involvement: 1 mg intramuscularly on alternate days until no further improvement, then 1 mg every 2 months [3] [4] Without neurological involvement: 1 mg intramuscularly three times a week for 2 weeks, then 1 mg every 2-3 months for maintenance [3] [4] There is some evidence that high-dose oral B12 (1000-2000 micrograms daily) may be effective even in some malabsorption conditions, though UK practice still generally favours intramuscular treatment in these cases

Dosing: Start 0.75 mg SC once weekly at any time of day, with or without meals

Leibel RL, Rosenbaum M, Hirsch J

L., Song, Y., Vidal-Alaball, J., & Liu, T

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While these findings are encouraging, further human trials are needed to confirm the effectiveness of this approach