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At the 12-month timepoint, the BMI on average decreased by 5.61 units in the semaglutide group and increased by 0.7 units in the empagliflozin group

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In the group given ALCAR, scores on the Montreal Cognitive Assessment improved significantly compared to the placebo group

To examine the involvement of GLP-1R signaling, Ex(9-39) (200 nmol kg 1 ) or saline was i.p