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Following release, the action of GH is achieved through binding with GH receptor (GHR), which is widely expressed in variety of tissues (Mller and Jrgensen, 2009) and their interaction mainly results in the activation of JAK2/STAT5, MAPK-ERK1/2, PI3K-Akt, as well as PLC/PKC/Ca 2+ signaling pathways (Zhu et al., 2001

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