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Journal of Clinical Investigation, 116 (7), 1776-1783
Quick Answer: GLP-1 medications show clinically meaningful average weight loss in large-scale peer-reviewed trials - approximately 14.9% for semaglutide (STEP 1) and up to 20.9% for tirzepatide (SURMOUNT-1) under trial conditions
hence, we could not verify if the decrease in mortality was related to a decrease in cardiovascular mortality or other disease categories
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