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The net effect is the activation of cGMP-dependent protein kinase (PKG

The compound showed an in vitro NNMT IC 50 of approximately 1.2 M and did not inhibit related methyltransferases at concentrations tested

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Nowowiejska L, Marek-Jzefowicz L, Szewczyk-Golec K, Woniak A, Basaygo M, Zegarska B, et al

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A medication costing $1,200 monthly that produces 50 lbs of weight loss over a year represents roughly $290 per pound lost