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From gut to brain: Peripheral BPC-157 administration increased serotonin synthesis in substantia nigra, produced antidepressant effects in Porsolt tests, and counteracted serotonin syndrome behavioral manifestations

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Methods Protocol and Registration This scoping review was conducted following the methodological framework of the Joanna Briggs Institute (JBI) for scoping reviews [7] and is reported according to the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) checklist [8]

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Reported pharmacokinetic data give BPC-157 a short elimination half-life of roughly 1530 minutes in rodent and canine models, whereas TB-500 is reported with a longer serum half-life of about 2.53 hours plus prolonged tissue availability

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