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doi: 10.3389/fendo.2024.1503905 Received 29 September 2024 Accepted 09 December 2024 Published 09 January 2025 Volume 15 - 2024 Edited by Weibin Bai, Jinan University, China Reviewed by Zia Ur Rehman, University of Agriculture, Pakistan Kamil Gill, Pomeranian Medical University, Poland Updates Copyright 2025 Saleh, Sallam, Elsuity, Dutta, Sengupta and Nasr

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In Amaranthus and blackgrass, targeting eccDNA maintenance through inhibition of replicon encoded replication or recombination factors, disruption of tethering motifs, or epigenetic re-silencing of TE-rich circles could reduce the rate at which resistant genotypes arise and are maintained under herbicide pressure