The GPX4 encoded proteins exhibit distinct subcellular sites of localization including the nucleus, the mitochondria, and the cytosol
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Ageing Res Rev 72:101510 Zeng L, Jin X, Xiao QA, Jiang W, Han S, Chao J, Zhang D et al (2024) Ferroptosis: action and mechanism of chemical/drug-induced liver injury
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Similarly, in kidney cells exposed to cadmium background, SIRT3 levels were downregulated, GPX4 acetylation levels were upregulated, and lipid peroxidation levels were upregulated, inducing ferroptosis[137]
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