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Most people who undergo chemotherapy and/or radiation report significant fatigue
doi: 10.1111/j.1532-5415.1988.tb04397.x 27 InfanteMLeoniMCaprioMFabbriA
Too much estrogen being metabolized through CYP1B1 into 4-OHE1(E2) and the estrogen quinones can potentially be bad if your body has slower phase II (COMT, GSTP1, GSTM1, NQO1) enzymes.[ref][ref] The connection between smoking and estrogen-related cancers: Smoking significantly increases the risk of breast cancer and prostate cancer
Br Med J 1958
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