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PMID 33189083

The thing is, there is no pharmacologically superior day to inject tirzepatide

These mice without BTBD9 were more active when they should be resting, had disturbed sleep, and were more sensitive to temperature.[ref] Circadian regulation of dopamine: Brain imaging studies show that there may be an evening and nighttime dopamine deficit in the striatum due to increased daytime receptor function.[ref] There is an overall circadian rhythm to dopamine production, and it is naturally lower at night and higher during the day

doi: 10.3389/fonc.2025.1702219 7 TianHCaoJLiBNiceEMaoHZhangY

In patients also taking insulin, sulfonylureas, or metformin, this can be life-threatening

While it has shown promise for weight loss, especially among individuals with diabetes, there are significant risks and side effects associated with its use