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[1] [2] While high-dose oral B12 supplements can be effective through passive diffusion, they are not routinely recommended for pernicious anaemia management in UK practice

In August 2025, semaglutide became the first GLP-1 medication to receive FDA approval specifically for treating MASH

Central nervous system effects : GLP-1 receptors in the brain influence appetite and nausea perception, contributing to the commonly reported nausea

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Market sentiment also reflects policy concerns