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Whole-blood measurements are dominated by erythrocyte glutathione and require appropriate volume- or erythrocyte-based normalization, whereas plasma and serum contain much lower concentrations and are particularly sensitive to hemolysis and processing delay

Cullin 5-RING E3 ubiquitin ligases, new therapeutic targets

doi: 10.1016/j.cell.2012.03.042 14

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This is because folic acid is effective at rejoining breaks in the fibroblast DNA