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Pro-inflammatory and proatherogenic mCRP, but not nCRP, induces ROS monocyte/macrophage production and facilitates macrophage uptake of necrotic cells (170, 192) contributing to foam cell formation, atherosclerotic plaque formation and plaque rupture or destabilization (190, 191)
Fibrates and TZDs have both shown beneficial cardiovascular effects in clinical trials 3,10,11 , which together with their complementary action on glucose and lipid metabolism spurred the development of PPAR/ dual agonists (Glitazars) for the treatment of type 2 diabetes (T2D) and dyslipidaemia 1
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At baseline, the mean systolic blood pressure was 135.5 mmHg, the mean diastolic blood pressure was 78.1 mmHg, the mean LDL was 95.0 mg/dL, and the mean HDL was 44.0 mg/dL
This is the same mechanism that makes GLP-1 agonists like semaglutide effective for weight management
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