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SOURCE NV Perricone
[93] [14] It is given intravenously
GLP-1 medications slow gastric emptying
Cheung AS, Pattison D, Bretherton I, Hoermann R, Lim Joon D, Ho E, et al
This partial agonism is intrinsic to orforglipron's binding mode: as an allosteric agonist occupying a smaller binding pocket with fewer receptor contacts than peptide ligands, it stabilizes a receptor conformation that is somewhat less efficient at coupling to Gs proteins than the fully peptide-activated state
PMID: 35678309
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