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Indeed, in physiological conditions, plasma GLP-1 has been suggested to increase not only after meals, but also in the pre-ingestive, cephalic phase, with its peak observed about an hour prior to meal initiation in rats [55]
There's now some upside in HIMS even without GLP-1 growth, but I believe that caution is warranted for now
doi: 10.1176/ajp.2006.163.11.1905 171 SahayA.HenR
But research over the past several years has made one thing clear: The brain plays a central role in how these drugs suppress appetite
Combinations of Treatment Methods As GLP-1 RA and amylin analog-induced weight loss arise from both distinct and overlapping mechanisms, the combination of GLP-1 RA and amylin RA has been shown to produce a synergistic effect [118]