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The 500 Dalton rule suggests small peptides can cross the stratum corneum, but intact copper coordination and hydrophilicity reduce net penetration

GHK-Cus expansive published evidence base simplifies literature justification in protocol documentation, grant applications, and institutional review submissions

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the peptide is hydrophilic and relatively large, so most of a topical dose does not reach viable dermis without delivery enhancement

BPC-157 is a synthetic version of a protective fragment derived from a human stomach protein