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For prodrugs targeting other SLC transporters, such as Glucose transporter 1 (GLUT1), sodium-dependent vitamin C transporter 2 (SVCT2) and Organic cation/carnitine transporter 2 (OCTN2), there is even less information available as the transport kinetics have not been investigated for prodrugs targeted to these transporters
In addition, FIN56 induced coenzyme Q10 (CoQ10) depletion through interaction with squalene synthase (SQS), thereby increasing the sensitivity of cells to ferroptosis [128]
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Discovery of the once-weekly glucagon-like peptide-1 (Glp-1) analogue semaglutide
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