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Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model Annals of Clinical and Laboratory Science, 2015 Summer, Volume 45 (Issue 4), Pages 426-32

Brain Res 217:339349 Singhal SS, Yadav S, Roth C, Singhal J (2009) RLIP76: A novel glutathione-conjugate and multi-drug transporter

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The peptide decreased the fluorescence intensity of H2AX signals, a marker of DNA damage, and appeared to have lowered apoptosis rates as indicated by Annexin-V staining

However, depletion of CoQ10 leads to squalene synthase SQS triggering ferroptosis in response to the agonist FIN56 [76, 151]

If irritation is persistent or severe, reducing dose or frequency may help