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This favorable safety margin provides reassurance, though extrapolation from animals to humans always involves uncertainty
They can also be used to prevent and treat endocrine disorders or metabolic diseases such as polycystic ovary syndrome (PCOS), obesity, and non-alcoholic fatty liver disease (NAFLD) (135)
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Melanotan 2, by contrast, demonstrates broader receptor specificity, interacting notably with the MC1, MC3, and MC4 receptors
N Engl J Med 375(19):18341844 Marx N, Husain M, Lehrke M, Verma S, Sattar N (2022) GLP-1 receptor agonists for the reduction of atherosclerotic cardiovascular risk in patients with type 2 diabetes
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