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Physiology of peripheral and central GLP-1 signaling GLP-1 is a 30-amino acid peptide synthetized by enteroendocrine L cells of the small and large intestine, and also in the brain primarily by neurons of the nucleus tractus solitarius (NTS) within the caudal brainstem as a product of tissue-specific posttranslational cleavage of a larger precursor molecule preproglucagon (PPG)
After being approved, a treatment program that is tailored to the individual needs of the patient will need to be developed
However, through the $10 billion acquisition of clinical-stage biotech company Metsera in November 2025, Pfizer secured a next-generation obesity pipeline after an aggressive bidding war with Novo
Science 375, 12541261
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