At the same time, patients with long-lasting disease (maximum duration 35 years) were not excluded from the study, suggesting that oral semaglutide may also be a therapeutic choice in patients with longer disease evolution
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Through stimulation of pro-opiomelanocortin (POMC) neurons while simultaneously inhibiting neuropeptide Y/agouti-related peptide neurons in the arcuate nucleus, GLP-1 receptor agonism promotes satiety, reduces meal size, and decreases overall caloric intake [35]
The development of GLP-1 analogues like semaglutide has ushered in a new era of obesity treatment, offering hope to millions struggling with weight management and related health issues