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62 FuruhashiS.SugitaH.TakamoriH.HorinoK.NakaharaO.OkabeH.et al (2012)

Due to the presence of heterogeneity in the included studies (I 2 = 80%, P = 0.0001), the random effects model was used (Fig

The investigators reported partial restoration of the circadian melatonin rhythm in elderly subjects following the epithalamin course, with measurable but incomplete return toward younger-adult patterns of nocturnal melatonin secretion [2]