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Toxic substances in cigarette smoke have the potential to increase free radicals, malondialdehyde (MDA) levels and to decrease endogenous antioxidant (glutathione/GSH) levels

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Our laboratory as well as other investigators, have instigated a major effort in studying antihormone resistance in breast cancer and have developed model systems of estrogen deprivation that are sensitive [46] or resistant to the apoptotic actions of estrogen [7]

Then somewhere around month five or six, things level out

Oxidative damage and protection of the RPE