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The mechanism of action involves several pathways that collectively improve glycaemic control and promote weight loss

B12 injections deliver hydroxocobalamin (the preferred formulation in the UK) or cyanocobalamin directly into muscle tissue, bypassing the gastrointestinal tract to ensure rapid absorption into the bloodstream

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Intervention studies with glutathione precursors (particularly cysteine and glycine) show improvements in insulin sensitivity and mitochondrial function in older adults

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Currently, there is no definitive consensus that GLP-1 receptor agonists directly cause clinically significant bone density loss independent of their weight-reducing effects