Jumping to high doses too quickly dramatically increases nausea, vomiting, and other GI symptoms without producing faster weight loss
This is significant because current lupus nephritis management relies heavily on immunosuppressants (mycophenolate, cyclophosphamide, voclosporin) and biologics (belimumab, rituximab)
About this article Cite this article Liu, X., Goldberg, E., Kagan, J.C
Higher predisposition to adverse effects Additionally, people who had previously used gastrointestinal medications -- which may indicate they are more vulnerable to the common adverse gastrointestinal side-effects reported by GLP1-RA users, such as nausea, vomiting, diarrhea -- were 9% more likely to discontinue semaglutide within the first year
Discussing strategies for treatment continuityincluding addressing financial barriers, managing side effects proactively, and establishing realistic long-term goalsis essential for sustained benefit
Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death