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IV drips provide higher amounts of NAD+ (typically 125500 mg) slowly over 60120 minutes, which allows for deeper cellular repair and more sustained benefits
10.2215/CJN.02440222 111 MehtaR.CaiX.HodakowskiA.LeeJ.LeonardM.RicardoA.et al (2017)
For details about brand-name options, please consult your licensed healthcare provider or pharmacist
Lean tirzepatide when: Maximum weight loss is the goal (target greater than 20%) You have T2D with significant insulin resistance (SURPASS-2: 11.2 kg tirzepatide vs 5.7 kg semaglutide) You have moderate-to-severe obstructive sleep apnea with obesity (Zepbound is the only FDA-approved pharmacotherapy) You plateaued on semaglutide after 12+ months You have MASH and need the drug with the strongest resolution data (SYNERGY-NASH: 44 to 62% resolution) Your insurance covers Zepbound or Mounjaro You tolerated the 2.5 mg starting dose well during a prior trial Lean semaglutide when: You have established cardiovascular disease or high CV risk
Even so, growing evidence suggests that a significant number of patients stop taking these drugs not long after beginning, and until recently, reliable population-level data on discontinuation have been scarce
Zhai Z, Zou P, Liu F, Xia Z, Li J
