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This is a plausible biological hypothesis, and it is the reasoning most often cited in research-community discussions of combined protocols

Large-scale, well-designed trials with proper randomization and blinding are needed to determine whether high-dose oral supplementation is as effective as intramuscular injection for increasing vitamin B 12 status and alleviating clinical symptoms of vitamin B 12 deficiency

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Nine tendons and the median nerve must pass through this remarkably small space, explaining why even minor swelling causes significant problems

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